Challenges of total hip arthroplasty in patients with sickle cell disease

Elido Perez, MD; Delfilio Martinez, MD; Jose Taveras, MD

Sickle cell anemia (SCA), the most common and severe form of the disease, arises from a point mutation in the β-globin gene, leading to the production of abnormal hemoglobin S (HbS).

Difficult-to-treat sports foot, ankle injuries require appropriate management for return to sport

Leah Lawrence

Fractures and soft tissue injuries are a major concern for athletes. Appropriate management should include comprehensive diagnostic evaluations, considerations of surgical and non-surgical treatment options, and tailored rehabilitation programs.

PGE2 reduces age‑related rotator cuff atrophy

A new study presented Monday and Tuesday at the AAOS 2026 Annual Meeting investigated how prostaglandin E2 (PGE2), a regulator of muscle regeneration, affects muscular structure and mitochondrial function in aged mice.